An integrative analysis of biological and clinical data can help researchers develop a deeper appreciation of the principles underpinning life. Towards this goal, we construct integrative models of complex pathologies such as cancer to as far as building decision support systems for conditions such as pregnancy. The current research focuses of BIRL include multiscale integrative investigation of cancer, development of next-generation cancer modelling software, top-down proteomics search engine, drug development of Hepatitis-C virus and e-health monitoring systems.