The central dogma of molecular biology considers RNA as passive copy of DNA carrying the genetic information from nucleus to ribosomes for the production of proteins. However, RNA research over last three decades has shattered that long-held belief. We have witnessed discoveries showing non-coding RNAs including small interfering (si) RNAs, micro (mi)-RNAs, long non-coding (lnc-RNAs), CRISPER and circular RNAs acting as critical regulatory genes. Equally amazing is the translation of these breakthroughs to therapy. RNA Therapeutics Lab at LUMS is interested to exploit array of opportunities provided by these non-coding RNAs for understanding and targeting of disease-associated pathways. The long-term objective of the lab is to use RNA-based therapeutics for human diseases including cancer. Currently we are working on two aspect of RNA biology, first deals with therapeutic potential of RNA and second deals with discovery of basic mechanisms of miRNA biogenesis by RNA binding proteins.
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